Cytidine triphosphate synthase 2 (CTPS2)

Cytidine triphosphate synthase 2 is an enzyme encoded by the CTPS2 gene in humans. It catalyzes the rate-limiting step in the de novo synthesis of cytidine triphosphate (CTP) from uridine triphosphate (UTP) with the concomitant deamination of glutamine to glutamate, a reaction essential for the biosynthesis of RNA, DNA, and phospholipids. CTPS2 is tightly regulated by substrate/product levels and phosphorylation, can form dynamic filaments (cytoophidia) in cells, and is more active in proliferating or malignant cells. As such, it is considered a promising therapeutic target for conditions characterized by abnormal cell growth, such as cancer and hematological malignancies. Its role in DNA damage response and repair also links it to genome stability and cancer pathogenesis[1][3][4][5][7].

Other names

CTP synthase 2CTPS2Cytidine triphosphate synthetase 2

Inhibition of CTP biosynthesis, reducing nucleotide availability for DNA/RNA synthesis and thus limiting cell proliferation [1][3][7] - Disruption of DNA damage repair and replication by reducing cytidine nucleotide pools [5]