Cytochrome b pseudogene

The cytochrome b pseudogene is a nuclear DNA sequence derived from the mitochondrial cytochrome b gene via translocation (NUMT, nuclear mitochondrial DNA segment). It accumulates mutations, indels, and frame-shifts that render it non-functional, and it cannot be translated into an active protein. These pseudogenes can be accidentally amplified during molecular genetic studies, potentially leading to analytical errors. While originally considered non-functional, some pseudogenes (including cytochrome b pseudogene) may play regulatory roles as non-coding RNA in cellular networks such as the ceRNA network. This pseudogene is not considered a therapeutic target and has no known drug interactions, but must be appropriately identified to avoid confusion in genetic or biomarker studies.

Other names

CYTB pseudogenecytochrome b NUMTmitochondrial cytochrome b pseudogene