Cytochrome b reductase 1 (CYBRD1)

Cytochrome b reductase 1 (CYBRD1) is a plasma membrane-associated reductase enzyme, highly expressed on the brush border membrane of duodenal enterocytes in humans. It catalyzes the ascorbate-dependent reduction of ferric (Fe3+) to ferrous (Fe2+) iron, a critical biochemical step for dietary iron absorption. CYBRD1 is a member of the cytochrome b(561) family and is regulated by iron status and hypoxia, mediated by the HIF2 transcription factor. While most studied in intestinal iron metabolism, CYBRD1 is also expressed in other tissues such as lungs, erythrocytes, and breast tissue, where it may contribute to ascorbate metabolism and extracellular oxidoreductase processes. Genetic variation in CYBRD1 influences iron status and may relate to disease states including iron overload syndromes and cancer prognosis.

Other names

Plasma membrane ascorbate-dependent reductase CYBRD1DCYTBFRRS3FLJ23462CYB561A2Duodenal cytochrome bFerric-chelate reductase 3cytochrome b561 family member A22210407P13RikMGC122108CYTBDcytb

For hypothetical small molecule or biologic targeting, possible mechanisms include: - Inhibition or modulation of ferric reductase activity to alter iron uptake - Modulation of expression for indirect impact on iron absorption