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Target intelligence / Profile preview
Cytochrome b subunit of cytochrome bc1 complex (QcrB) (QcrB)
- Target
- QcrB
- Molecular classification
- Enzyme, Electron Carrier, Mitochondrial protein, Membrane protein
01
Overview
The cytochrome b subunit is a core component of the cytochrome bc1 complex (Complex III) in the electron transport chain. It plays a crucial role in the Q-cycle mechanism, facilitating electron transfer from ubiquinol to cytochrome c and contributing to proton translocation across the mitochondrial membrane, ultimately driving ATP synthesis. Mutations in this subunit are associated with mitochondrial diseases. It is a target for various inhibitors used in clinical therapy and agriculture.
- Other names
- Complex III subunit cytochrome bCytochrome b
02
Mechanism of action
Inhibition of electron transport at the bc1 complex
03
Biological functions
Electron transportEnergy transductionProton translocationATP synthesis
04
Disease associations
Mitochondrial myopathiesMultisystem disorders
05
Safety considerations
Increased production of reactive oxygen species
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