Cytochrome b5 reductase-like (CYB5RL)

Cytochrome b5 reductase-like (CYB5RL) is a human protein belonging to the oxidoreductase family, showing sequence similarity to bona fide cytochrome b5 reductases. These enzymes transfer electrons from NADH or NADPH to cytochrome b5 and other substrates, participating in redox reactions critical for lipid metabolism, cholesterol biosynthesis, and erythrocyte methemoglobin reduction. CYB5RL is predicted to possess cytochrome-b5 reductase activity and may function in electron transfer and bicarbonate transport, but its biological roles are only partially characterized. Disease associations include sulfhemoglobinemia and a congenital syndrome, though there is minimal evidence for direct drug interactions or biomarker utility at present.

Other names

NADH-cytochrome b5 reductase-likeLOC606495NB5R5_HUMANQ6IPT4

Not established for CYB5RL specifically; for cytochrome b5 reductase family, mechanisms typically involve electron transfer from NADH/NADPH to facilitate reduction reactions, often with cytochrome b5 as the acceptor