Cytochrome b561 family member D1 (CYB561D1)

Cytochrome b561 family member D1 (CYB561D1) is a probable transmembrane reductase belonging to the cytochrome b561 protein family. It is characterized by a core motif forming a four helix bundle with conserved histidine residues that coordinate two heme groups. This protein facilitates electron transfer across cellular membranes, primarily using ascorbate as an electron donor, which is important for ascorbate regeneration and overall redox balance. While other cytochrome b561 family members have established roles in iron metabolism, ascorbate recycling, and electron transport, the precise physiological and pathological functions of CYB561D1 remain incompletely understood. The cytochrome b561 family includes several transmembrane oxidoreductases with versatile electron transport abilities, classified into subfamilies by motif and phylogeny. CYB561D1 is considered a probable member of this family, predicted to play roles in maintaining redox status rather than directly impacting disease processes or serving as a well-validated drug target. No established disease associations, drug interactions, or biomarker applications were found in available sources.

Other names

CYB561D1probable cytochrome b561 domain-containing protein D1