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Target intelligence / Profile preview
Mitochondrial Respiratory Chain Complex III (Complex III)
- Target
- Complex III
- Molecular classification
- Enzyme, Multi-subunit enzyme, Respiratory chain complex
01
Overview
Mitochondrial respiratory chain complex III, also known as cytochrome bc1 complex or coenzyme Q – cytochrome c reductase, is a critical multi-subunit enzyme embedded in the inner mitochondrial membrane. It facilitates electron transfer from ubiquinol to cytochrome c, contributing to the generation of a proton gradient used for ATP synthesis. It's a central component of the electron transport chain and is involved in supercomplex formation, ROS generation, and oxygen sensing.
- Other names
- Cytochrome bc1 complexCoenzyme Q – cytochrome c reductaseUbiquinol-cytochrome c reductase
02
Biological functions
Electron transportProton pumpingATP synthesisReactive oxygen species generationOxygen sensingCellular respiration
03
Disease associations
Mitochondrial diseaseNeurodegenerative diseaseCardiovascular diseaseCancerHypoxia
04
Safety considerations
Potential for increased ROS productionComplex assembly disruptionCombined deficiencies affecting other respiratory complexes
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