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Target intelligence / Profile preview
Cytochrome c oxidase (Complex IV) (COX)
- Target
- COX
- Molecular classification
- Enzyme, Oxidoreductase, Mitochondrial respiratory chain complex
01
Overview
Cytochrome c}
- Other names
- Complex IVFerrocytochrome c:oxygen oxidoreductaseMitochondrial respiratory chain complex IV
02
Mechanism of action
Inhibition of the terminal enzyme in the mitochondrial electron transport chain, leading to the blockage of electron transfer to oxygen, depletion of ATP, and induction of apoptosis-like cell death.
03
Biological functions
Cellular respirationATP synthesisElectron transportOxygen reductionMaintenance of mitochondrial membrane potential
04
Disease associations
LeishmaniasisInfection
05
Safety considerations
Potential cross-reactivity with human mitochondrial complexesDrug resistanceTeratogenicity (associated with miltefosine)Gastrointestinal toxicity
06
Interacting drugs
Miltefosine
3 more in the full profile.
07
Biomarkers
Mitochondrial membrane potentialIntracellular ATP levelsOxygen consumption rateReactive oxygen species (ROS)
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