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Target intelligence / Profile preview
Cytochrome c oxidase assembly factor 5 (COA5)
- Target
- COA5
- Molecular classification
- Other (Mitochondrial assembly factor)
01
Overview
Cytochrome c oxidase assembly factor 5 (COA5) is a mitochondrial protein required for early steps in the assembly of cytochrome c oxidase (Complex IV), a key enzyme of the respiratory electron transport chain responsible for cellular energy production. COA5 acts as an assembly factor rather than a catalytic subunit, and mutations in COA5 are associated with mitochondrial diseases characterized by impaired Complex IV activity and resulting defects in oxidative phosphorylation[4][2].
- Other names
- Cytochrome c oxidase assembly factor 5COA5C2orf64MGC52110FLJ27524PET1916330578E17RikCEMCOX3MC4DN9Pet191protein C2orf64
02
Biological functions
Mitochondrial complex IV (cytochrome c oxidase) assemblyElectron transport chain biogenesis
03
Disease associations
Other (Mutations cause mitochondrial complex IV deficiency)
04
Biomarkers
Potential: mutations in COA5 as a genetic marker for mitochondrial complex IV deficiency
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