Cytochrome c oxidase subunit 7B (COX7B)

Cytochrome c oxidase subunit 7B (COX7B) is a nuclear-encoded protein that forms part of the cytochrome c oxidase (Complex IV) enzyme complex within the mitochondrial inner membrane[2]. This complex is the terminal component of the mitochondrial respiratory chain, catalyzing the final step of electron transfer from cytochrome c to molecular oxygen, ultimately driving ATP synthesis through oxidative phosphorylation[2][4]. COX7B is essential for proper assembly and catalytic activity of Complex IV; its dysfunction leads to impaired mitochondrial respiration, and mutations are associated with congenital syndromes such as microphthalmia with linear skin defects, microcephaly, and other developmental anomalies[2]. Recent evidence suggests a role for COX7B in cancer cell metabolism, particularly as a driver of oxidative phosphorylation and brain metastatic propensity in breast cancer models, highlighting its potential as both a biomarker and a candidate therapeutic target for tissue-specific metastasis[4].

Other names

COX7BCytochrome c oxidase polypeptide VIIbCytochrome c oxidase subunit VIIb, mitochondrial

Inhibition of cytochrome c oxidase activity (by broad-spectrum inhibitors such as cyanide, azide, carbon monoxide); Modulation of OXPHOS in the context of gene expression changes or RNA interference, rather than pharmacological targeting