Cytochrome c pseudogene 19 (CYCSP19)

CYCS pseudogene 19 (CYCSP19), also known as HCP19, is not a functional protein-coding gene but a pseudogene derived from the human cytochrome c gene (CYCS)[1][4]. It is not a recognized therapeutic target, and key details about its function, relevance, and clinical implications are outlined below. Cytochrome c pseudogene 19 (CYCSP19; HCP19) is one of 49 processed pseudogenes identified in the human genome sharing sequence similarity with the functional cytochrome c gene (CYCS), which encodes a mitochondrial protein involved in electron transport and apoptosis[1][4]. These pseudogenes, including CYCSP19, typically lack introns and often possess characteristic disablements in their coding sequence, such as frame shifts and premature stop codons, rendering them unable to produce functional proteins[1][4]. The processed pseudogenes originated through retrotransposition events and are widely distributed across many chromosomes but have not been shown to be transcribed or translated[1][2][4]. There is no evidence that CYCSP19 is expressed, nor is there any known clinical or therapeutic relevance for this pseudogene[1][4]. No information supports a functional, regulatory, or disease-associated role for CYCSP19 specifically; its main significance is as a genomic relic of cytochrome c gene evolution[1][4].

Other names

HCP19cytochrome c pseudogene 19