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Target intelligence / Profile preview
Cytochrome P450 1A1 (CYP1A1)
- Target
- CYP1A1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
CYP1A1 is an extrahepatic cytochrome P450 monooxygenase crucial for both detoxifying harmful compounds and activating certain procarcinogens. Its dual role makes it significant both physiologically—for normal metabolic processing—and pathologically—in cancer risk associated with environmental exposures. Its expression is tightly regulated by environmental factors through AhR signaling pathways.
- Other names
- Cytochrome P450, family 1, subfamily A, polypeptide 1
02
Mechanism of action
Monooxygenation; Oxidation
03
Biological functions
Phase I drug metabolismXenobiotic metabolismDetoxificationProcarcinogen activationSteroid hormone metabolismFatty acid metabolism
04
Disease associations
CancerOxidative Stress
05
Safety considerations
Procarcinogen activation leading to DNA adduct formation and mutationsIncreased production of reactive metabolitesIncreased free radical generation
06
Interacting drugs
Theophylline
5 more in the full profile.
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