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Target intelligence / Profile preview
Cytochrome P450 11B2 (CYP11B2)
- Target
- CYP11B2
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 11B2 (CYP11B2), also known as aldosterone synthase, is a mitochondrial enzyme that catalyzes the final three steps in the biosynthesis of aldosterone, regulating blood pressure by controlling sodium and water retention and potassium excretion. It is expressed predominantly in the zona glomerulosa of the adrenal cortex. Mutations or dysregulation can lead to aldosterone synthase deficiency, familial hyperaldosteronism, or primary hyperaldosteronism. Targeted inhibition of CYP11B2 is being explored as a treatment for primary hyperaldosteronism.
- Other names
- Aldosterone synthaseCorticosterone methyloxidase IISteroid 11-beta-hydroxylase
02
Mechanism of action
Metabolizes steroid-based drugs; targeted inhibition of CYP11B2-mediated aldosterone production is being explored
03
Biological functions
Steroid hormone biosynthesisRegulation of blood pressureSodium and water retentionPotassium excretion
04
Disease associations
Corticosterone methyloxidase deficiency (aldosterone synthase deficiency)Familial hyperaldosteronism type IPrimary hyperaldosteronism/Conn’s syndromeHypertensionCardiovascular disease
05
Safety considerations
Mutations or dysregulation can lead to insufficient production of aldosterone or overproduction of aldosterone.Inhibition remains an unrealized therapeutic option as per current literature.
06
Interacting drugs
Spironolactone
1 more in the full profile.
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