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Target intelligence / Profile preview
Cytochrome P450 14α-Demethylase (CYP51)
- Target
- CYP51
- Molecular classification
- Enzyme, Cytochrome P450 superfamily, Oxidoreductase
01
Overview
Cytochrome P450 14α-demethylase (CYP51) is a highly conserved enzyme crucial for sterol biosynthesis across all biological kingdoms. It catalyzes the removal of the 14α-methyl group from sterol precursors like lanosterol or obtusifoliol, a critical step in producing essential membrane sterols (ergosterol in fungi, cholesterol in animals). As a major target for azole antifungals, inhibiting CYP51 disrupts fungal cell viability. However, resistance mechanisms such as mutations or overexpression pose a significant clinical challenge.
- Other names
- Sterol 14α-DemethylaseLanosterol 14α-Demethylase
02
Mechanism of action
Inhibition of ergosterol synthesis
03
Biological functions
Sterol biosynthesisErgosterol synthesisCholesterol synthesisMembrane integrity
04
Disease associations
Infection
05
Safety considerations
Drug resistance (mutations, overexpression)Potential for off-target effects
06
Interacting drugs
Fluconazole
1 more in the full profile.
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