Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cytochrome P450 14-alpha-demethylase (CYP51)
- Target
- CYP51
- Molecular classification
- Enzyme, Cytochrome P450 superfamily, Monooxygenase, Heme protein
01
Overview
Cytochrome P450 14-alpha-demethylase (CYP51) is an essential enzyme in sterol biosynthesis, catalyzing the removal of the 14α-methyl group from sterol precursors like lanosterol in animals and eburicol in fungi. It is a critical drug target, particularly for antifungal azoles, and is involved in cholesterol and ergosterol production.
- Other names
- Sterol 14α-DemethylaseLanosterol 14α-demethylaseSterol 14-demethylaseP45014DM
02
Mechanism of action
Inhibition of sterol biosynthesis by binding to the heme iron, blocking demethylation reaction.
03
Biological functions
Sterol biosynthesisCholesterol biosynthesisErgosterol productionPhytosterol synthesisOxidation-reduction processResponse to drugsResponse to toxinsCell growth mode switching
04
Disease associations
InfectionCancer
05
Safety considerations
Drug resistance due to CYP51 mutationsDrug resistance due to CYP51 overexpression
06
Interacting drugs
Azoles (Imidazoles/Triazoles)
Beyond the preview
Go deeper on Cytochrome P450 14-alpha-demethylase (CYP51).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cytochrome P450 14-alpha-demethylase (CYP51).