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Target intelligence / Profile preview
Steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1)
- Target
- CYP17A1
- Molecular classification
- Enzyme, Cytochrome P450 monooxygenase
01
Overview
CYP17A1 is a critical steroidogenic enzyme that catalyzes 17α-hydroxylation and C17,20-lyase reactions, essential for glucocorticoid, androgen, and estrogen production. It is a therapeutic target, particularly in prostate cancer, and mutations can cause congenital disorders of steroidogenesis.
- Other names
- Cytochrome P450 17A1P450c17Steroid 17-hydroxylase/17,20-lyase
02
Mechanism of action
Inhibition of androgen synthesis
03
Biological functions
Steroid biosynthesisHydroxylationCarbon-carbon bond cleavage
04
Disease associations
Sexual development disordersAdrenal hyperplasiaHypertensionProstate cancer
05
Safety considerations
Mineralocorticoid excessGlucocorticoid deficiency
06
Interacting drugs
Abiraterone acetate
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