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Target intelligence / Profile preview
Cytochrome P450 1B1 (CYP1B1)
- Target
- CYP1B1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 1B1 (CYP1B1) is a heme-containing monooxygenase enzyme involved in the metabolism of various endogenous and exogenous compounds. It is predominantly expressed in extrahepatic tissues and plays a role in developmental processes, drug metabolism, and the synthesis/breakdown of lipids. CYP1B1 is implicated in diseases such as primary congenital glaucoma, cancer, obesity, hypertension, and atherosclerosis, making it a potential therapeutic target.
02
Mechanism of action
Selective inhibition or modulation of CYP1B1 activity
03
Biological functions
Drug metabolismSteroid synthesisLipid metabolismMonooxygenase activityArachidonic acid metabolismRetinol metabolismMelatonin hydroxylationDietary flavonoid metabolism
04
Disease associations
Primary congenital glaucomaCancerObesityHypertensionAtherosclerosisVascular disease
05
Safety considerations
Potential for off-target effects due to structural similarity with other cytochrome P450 enzymesBioactivation of procarcinogens leading to DNA adduct formationImpact on lipid metabolism affecting cardiovascular health
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