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Target intelligence / Profile preview
Cytochrome P450 21-hydroxylase (CYP21A2)
- Target
- CYP21A2
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 21-hydroxylase (CYP21A2) is a microsomal enzyme crucial for adrenal steroidogenesis, catalyzing the 21-hydroxylation of progesterone and 17α-hydroxyprogesterone to produce cortisol and aldosterone. Mutations in CYP21A2 cause congenital adrenal hyperplasia (CAH), leading to impaired cortisol and aldosterone synthesis and excess androgen production.
- Other names
- 21-hydroxylaseSteroid 21-hydroxylaseCYP21
02
Mechanism of action
Inhibition of 21-hydroxylation
03
Biological functions
Steroid hormone biosynthesisCortisol synthesisAldosterone synthesis21-hydroxylation of steroids
04
Disease associations
Congenital adrenal hyperplasia (CAH)
05
Safety considerations
Adrenal crisisSalt-wastingVirilization
06
Biomarkers
17α-hydroxyprogesterone levelsAndrogen levels
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