Cytochrome P450 2B2 (CYP2B2)

Cytochrome P450 2B2 (CYP2B2) is an enzyme found primarily in rat liver, belonging to the cytochrome P450 superfamily of heme-thiolate monooxygenases. It catalyzes the oxidative metabolism of a variety of endogenous and exogenous compounds, including drugs, toxins, and steroids. CYP2B2 is inducible by certain xenobiotics such as phenobarbital, a property leveraged in experimental pharmacology to study hepatic drug metabolism and enzyme regulation. Like other P450s, it functions via a complex catalytic cycle involving electron transfer and formation of a reactive iron-oxo species which oxidizes substrates. While CYP2B2 itself is not a direct target for human therapy, its homologs (such as human CYP2B6) are clinically significant due to their impact on drug metabolism, pharmacokinetics, and potential for adverse drug interactions.

Other names

Cytochrome P450, family 2, subfamily B, polypeptide 2CYP2B2P450 2B2Rat cytochrome P450 2B2

Substrate oxidation via monooxygenase catalysis; Induction by xenobiotics acting as transcriptional activators