Cytochrome P450 2C18 (CYP2C18)

Cytochrome P450 2C18 (CYP2C18) is a member of the cytochrome P450 superfamily of enzymes, which are membrane-bound hemeproteins primarily located in the endoplasmic reticulum (UniProt P33260). This enzyme plays a role in the oxidative metabolism of various endogenous compounds and exogenous substances, including clinical drugs and environmental toxins (NCBI Gene ID: 1562). While CYP2C18 is closely related to the more abundant CYP2C9 and CYP2C19, it is typically expressed at much lower levels in the human liver, which has led to less extensive characterization of its specific substrate profile (PubMed 8657531). However, it has been shown to metabolize drugs such as phenytoin, omeprazole, and cyclophosphamide in vitro (DrugBank DB00252; PubMed 8657531). Genetic variations in the CYP2C18 gene may contribute to differences in drug metabolism and susceptibility to certain toxicities, although its clinical significance is often overshadowed by its more prominent subfamily members (PubMed 10490891). Understanding CYP2C18 is important for a comprehensive view of the CYP2C cluster's role in pharmacogenetics and toxicology.

Other names

Cytochrome P450 family 2 subfamily C member 18CYPIIC18P450-6B/2CCytochrome P450-6BCytochrome P450-2C18

Catalyzes the oxidation of substrates by incorporating one atom of molecular oxygen into the substrate and reducing the other atom to water, typically using NADPH as an electron donor (UniProt P33260).