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Target intelligence / Profile preview
Cytochrome P450 2C8
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 2C8 (CYP2C8) is a member of the cytochrome P450 superfamily of enzymes. It functions as a monooxygenase and plays a crucial role in phase I metabolism, catalyzing the oxidative biotransformation of both endogenous compounds and xenobiotics, including many clinically important drugs. It is predominantly expressed in the liver, and genetic polymorphisms influence enzyme activity, leading to interindividual variability in drug response.
- Other names
- CYP2C8
02
Mechanism of action
Catalyzes oxidation reactions involved in drug metabolism. Exhibits epoxygenase activity: converts long-chain polyunsaturated fatty acids into biologically active epoxides.
03
Biological functions
Drug metabolismOxidation reactionsEpoxygenase activityMetabolism of fatty acidsMetabolism of steroid hormonesMetabolism of vitamins
04
Disease associations
CancerDiabetesMalaria
05
Safety considerations
Variability in CYP2C8 function can significantly affect drug efficacy and toxicity profiles.Drug-drug interactions due to inhibition or induction of CYP2C8
06
Interacting drugs
Paclitaxel
7 more in the full profile.
07
Biomarkers
CYP2C8*3 allele (affects metabolism of some substrates)
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