Cytochrome P450 2C8 and Cytochrome P450 3A4 (CYP2C8 and CYP3A4)

Cytochrome P450 2C8 (CYP2C8) and Cytochrome P450 3A4 (CYP3A4) are members of the cytochrome P450 enzyme superfamily, responsible for the oxidative metabolism of a wide variety of endogenous and exogenous compounds, including many clinically important drugs[3][5]. CYP2C8 is a key hepatic phase I enzyme participating in the biotransformation of xenobiotics and polyunsaturated fatty acids, while CYP3A4 is one of the most abundant P450 enzymes in the liver and intestines, playing a central role in the metabolism of more than half of all marketed drugs[3][5][6]. Both enzymes are critical determinants of drug clearance, efficacy, and drug-drug interactions, and are clinically relevant therapeutic targets in the context of predicting metabolism, safety, and efficacy of substrate drugs[1][4].

Other names

CYP2C8Cytochrome P4502C8P450 2C8CYP3A4Cytochrome P4503A4P450 3A4

Metabolic clearance via oxidation (phase I metabolism); Conversion of drugs to metabolites with variable activity or toxicity