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Cytochrome P450 2D1 (CYP2D1)
- Target
- CYP2D1
- Molecular classification
- Enzyme, Cytochrome P450 superfamily, Oxidoreductase, Monooxygenase
01
Overview
Cytochrome P450 2D1 (CYP2D1) is a rat liver enzyme belonging to the cytochrome P450 superfamily, functioning primarily as an oxidoreductase that catalyzes the metabolism of xenobiotics by monooxygenation. CYP2D1 is widely used in preclinical pharmacology as the rat counterpart to human CYP2D6, which is critically involved in the metabolism of many therapeutic drugs. CYP2D1 shares substantial sequence and functional similarity to CYP2D6, so inhibitors, inducers, and substrates often cross-react in experimental setups. Its study is essential for understanding interspecies differences in drug metabolism and toxicity, but "CYP2D1" is not relevant as a therapeutic target or biomarker in humans. If you require human clinical information, use Cytochrome P450 2D6 (CYP2D6) instead.
- Other names
- CYP2D1cytochrome P450, family 2, subfamily D, polypeptide 1rat cytochrome P450 2D1
02
Mechanism of action
Substrate oxidation via insertion of one atom of oxygen into organic molecules (monooxygenase reaction), making xenobiotics more hydrophilic for excretion
03
Biological functions
Xenobiotic metabolismOxidation of endogenous and exogenous compoundsDrug metabolism
04
Disease associations
Other (used in animal models for pharmacokinetic and toxicology studies; not directly linked to human disease but relevant for extrapolation in drug safety testing)
05
Safety considerations
Variable expression and induction/inhibition may affect drug metabolism in animal studies; not directly translatable to human clinical consequences
06
Interacting drugs
Common human CYP2D6 substrates and inhibitors are used in CYP2D1 rat studies (e.g., dextromethorphan, codeine, antidepressants)
07
Biomarkers
Metabolite profiles of administered drugs (e.g., dextromethorphan metabolic ratio) in rats
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