Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cytochrome P450 2D6 (CYP2D6)
- Target
- CYP2D6
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase, Heme-containing monooxygenase
01
Overview
Cytochrome P450 2D6 (CYP2D6) is a key enzyme in the cytochrome P450 superfamily, primarily expressed in the liver and also present in certain regions of the central nervous system. It plays a crucial role in metabolizing and eliminating approximately 20–25% of all clinically used drugs, including antidepressants, antipsychotics, analgesics (such as codeine), beta-blockers, and anticancer agents. CYP2D6 is also involved in activating some prodrugs and metabolizes several endogenous compounds like neurosteroids and tyramine derivatives. Genetic polymorphisms in CYP2D6 lead to varying levels of enzyme activity, impacting drug efficacy and toxicity.
- Other names
- CYP2D6P450 2D6Cytochrome P-450 2D6EC 1.14.14.1
02
Mechanism of action
Hydroxylation, demethylation, dealkylation of drugs and endogenous substrates.
03
Biological functions
Drug metabolismXenobiotic metabolismSteroid metabolismActivation of prodrugsInactivation of drugs
04
Disease associations
Adverse drug reactionsDrug resistancePharmacogenomics-related diseases
05
Safety considerations
Drug-drug interactionsAdverse drug reactions due to altered metabolismLack of efficacy due to impaired prodrug activationIncreased risk of toxicity due to decreased drug clearance
06
Interacting drugs
Antidepressants
6 more in the full profile.
07
Biomarkers
CYP2D6 genotypeCYP2D6 phenotype (PM, IM, EM/NM, UM)
Beyond the preview
Go deeper on Cytochrome P450 2D6 (CYP2D6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cytochrome P450 2D6 (CYP2D6).