Cytochrome P450 2F1 (CYP2F1)

Cytochrome P450 2F1 (CYP2F1) is a member of the cytochrome P450 superfamily of heme-containing monooxygenase enzymes, predominantly expressed in human lung tissue. CYP2F1 is involved in the oxidative metabolism of xenobiotics and endogenous toxins, catalyzing reactions such as monooxygenation and dehydrogenation of substrates like naphthalene, ethoxycoumarin, and 3-methylindole. These reactions contribute to drug metabolism, detoxification, and the biosynthesis of cholesterol and steroids. The enzyme is membrane-bound in the endoplasmic reticulum. Genetic variations in CYP2F1 may result in substantial interindividual differences in enzyme activity and susceptibility to chemically induced lung toxicity or carcinogenesis, although current evidence does not support a major direct role in lung cancer pathogenesis.

Other names

Cytochrome P450 family 2 subfamily F member 1CYPIIF1C2F1CYP2Fcytochrome P450, family 2, subfamily F, polypeptide 1cytochrome P450, subfamily IIF, polypeptide 1flavoprotein-linked monooxygenasemicrosomal monooxygenasexenobiotic monooxygenase

Oxidative metabolism (monooxygenation and dehydrogenation) of substrates including endogenous and xenobiotic compounds