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Target intelligence / Profile preview
Cytochrome P450 3A Enzyme (CYP3A)
- Target
- CYP3A
- Molecular classification
- Enzyme, Monooxygenase, Cytochrome P450, Hemoprotein
01
Overview
Cytochrome P450 3A enzymes (CYP3A) are a subfamily of monooxygenase enzymes responsible for metabolizing a large proportion of pharmaceutical drugs, as well as endogenous compounds such as steroid hormones and fatty acids. They are primarily expressed in the liver and intestine, and their activity is subject to genetic polymorphisms and environmental factors, leading to significant inter-individual variability in drug response and potential drug-drug interactions. Major human isoforms include CYP3A4, CYP3A5, CYP3A7, and CYP3A43.
- Other names
- CYP3A4CYP3A5CYP3A7CYP3A43
02
Mechanism of action
Oxidation (mainly hydroxylation and epoxidation) of substrates using NADPH and molecular oxygen as cofactors.
03
Biological functions
Xenobiotic metabolismDrug metabolismSteroid hormone metabolismBile acid metabolismFatty acid metabolismAmino acid metabolismDetoxification
04
Disease associations
Drug toxicityPharmacokinetics variabilityDrug-drug interactions
05
Safety considerations
Drug-drug interactionsVariability in drug responseDrug toxicityInter-individual differences in drug metabolism
06
Interacting drugs
Many prescription medications
2 more in the full profile.
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