Cytochrome P450 3A2 (CYP3A2)

Cytochrome P450 3A2 is an enzyme found primarily in rodent liver microsomes. It belongs to the cytochrome P450 superfamily and mediates the oxidative metabolism of many drugs, steroids, and toxins. The core structure contains a heme-iron center, which, upon substrate binding, facilitates oxygen transfer and the chemical transformation of substrates. This enzyme is critical for drug clearance, and its activity is modulated by various inhibitors and inducers, leading to clinically relevant pharmacokinetic interactions. In humans, the closely related CYP3A4 isozyme fulfills a similar function and is central to many adverse drug events and therapeutic outcomes

Other names

CYP3A2Cytochrome P450 3A2P450 3A2

Drug substrate oxidation (hydroxylation, demethylation, etc.) Enzyme inhibition (e.g., competitive, non-competitive inhibition by ketoconazole, erythromycin) Enzyme induction (e.g., by rifampicin, carbamazepine)