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Cytochrome P450 3A7-CYP3A51P readthrough (CYP3A7-CYP3A51P)
- Target
- CYP3A7-CYP3A51P
- Molecular classification
- Enzyme, Cytochrome P450, Oxidoreductase
01
Overview
Cytochrome P450 3A7-CYP3A51P readthrough is a polymorphic protein formed by **readthrough transcription** between the adjacent CYP3A7 (protein-coding) and CYP3A51P (pseudogene) loci on chromosome 7[1][5]. This produces a novel cytochrome P450 isoform with a unique C-terminus, expressed only on specific alleles enabling correct splicing. CYP3A7, the major gene involved, is predominantly expressed in the fetal liver and plays a key role in metabolizing steroids and xenobiotics, including many clinical drugs[3][4]. The readthrough product shares the principal activities of the CYP3A family: hydroxylation of steroids (e.g., testosterone, DHEA) and biotransformation of xenobiotics, contributing to Phase I drug metabolism pathways. Variants may impact drug efficacy and safety, making this target relevant for pharmacogenetics and as a **therapeutic target** in specific contexts such as oncology and maternal-fetal medicine[1][4][5].
- Other names
- CYP3A7CYP3A7-3AP1CYP3A7-CYP3AP1CYP3A7.1LCYPIIIA7CYP3A7-CYP3A51P proteinCYP3A7-CYP3AP1 readthroughCytochrome P450 3A7Cytochrome P450-HFLA
02
Mechanism of action
Oxidative metabolism (monooxygenase activity as part of Phase I drug metabolism)[3][4].
03
Biological functions
Drug metabolismOxidation–reduction reactionsSteroid hormone metabolismXenobiotic metabolism
04
Disease associations
CancerNeonatal abstinence syndromeDisruption in steroid hormone synthesis (noted for closely related gene products)
05
Safety considerations
Genetic polymorphism may alter drug metabolism, leading to therapeutic failure or toxicity, particularly in cancer chemotherapy and during pregnancy[4]
06
Interacting drugs
Not explicitly listed for this specific readthrough isoform; parent gene CYP3A7 is known to metabolize many drugs, especially steroids and some chemotherapeutic agents[4].
07
Biomarkers
CYP3A7*1C allele (for cancer drug response)[4]
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