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Target intelligence / Profile preview
Cytochrome P450-dependent all-trans-retinoic acid 4-hydroxylase (CYP26)
- Target
- CYP26
- Molecular classification
- Enzyme, Cytochrome P450 superfamily
01
Overview
Cytochrome P450-dependent all-trans-retinoic acid 4-hydroxylase refers primarily to the CYP26 family of enzymes, especially CYP26A1, which catalyze the hydroxylation of all-trans-retinoic acid (atRA) at the 4-position. This reaction is a key step in retinoic acid catabolism and regulates its biological activity by converting atRA into less active metabolites such as 4-hydroxy-RA and subsequently 4-oxo-RA. It is involved in embryogenesis, cell differentiation and modulating response/resistance to systemic/topical retinol-based therapies.
- Other names
- CYP26A1CYP26B1CYP26C1Retinoic acid 4-hydroxylase
02
Mechanism of action
Inhibition of retinoic acid metabolism
03
Biological functions
Retinoic acid catabolismRegulation of retinoic acid levelsXenobiotic metabolism
04
Disease associations
CancerDermatological disordersEmbryogenesis abnormalities
05
Safety considerations
Altered sensitivity or resistance to retinoid therapiesPotential for drug-drug interactions due to CYP450 involvementEmbryotoxicity if retinoid levels are dysregulated during pregnancy
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