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Target intelligence / Profile preview
Cytochrome P450-Dependent Steroidogenic Enzymes (Steroidogenic CYPs)
- Target
- Steroidogenic CYPs
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450-dependent steroidogenic enzymes are a family of heme-containing monooxygenases that catalyze key steps in the biosynthesis of steroid hormones from cholesterol. These enzymes, including CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, and CYP21A2, are essential for the production of glucocorticoids, mineralocorticoids, and sex steroids. Their activity is tightly regulated and alterations can lead to various endocrine disorders. CYP17A1, in particular, has dual 17α-hydroxylase and 17,20-lyase activities, making it a crucial branch point in steroidogenesis. Inhibition of these enzymes is a therapeutic strategy for conditions like prostate cancer.
- Other names
- Steroidogenic cytochrome P450sSteroid hormone biosynthesis enzymesCYP11A1CYP11B1CYP11B2CYP17A1CYP19A1CYP21A2
02
Mechanism of action
Inhibition of steroid hormone synthesis by blocking specific CYP enzyme activity.
03
Biological functions
Steroid hormone biosynthesisCholesterol metabolismEndocrine regulation
04
Disease associations
Congenital adrenal hyperplasiaHormonal imbalancesProstate cancerEndocrine disorders
05
Safety considerations
Hormonal imbalancesAdverse effects related to steroid hormone deficiency or excessDrug-drug interactions due to CYP inhibition
06
Interacting drugs
CYP17A1 inhibitors (e.g., abiraterone)
3 more in the full profile.
07
Biomarkers
Steroid hormone levels (cortisol, aldosterone, testosterone, estradiol)ACTH levels
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