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Target intelligence / Profile preview
Cytochrome P450-derived Eicosanoid Pathway (CYP450 Eicosanoid Pathway)
- Target
- CYP450 Eicosanoid Pathway
- Molecular classification
- Enzyme Pathway, Metabolic Pathway
01
Overview
The cytochrome P450-derived eicosanoid pathway is a crucial enzymatic route for metabolizing polyunsaturated fatty acids (PUFAs), particularly arachidonic acid, into bioactive lipid mediators. Key enzymes include epoxygenases (CYP2C/CYP2J) that produce vasodilatory EETs and ω-hydroxylases (CYP4A/CYP4F) that produce vasoconstrictive HETEs. This pathway plays a diverse role in vascular tone regulation, inflammation modulation, angiogenesis, and tumorigenesis. Alterations in this pathway are implicated in several diseases, including hypertension, inflammatory disorders, and cancer, making it a target for therapeutic intervention.
- Other names
- Cytochrome P450 Eicosanoid MetabolismCYP Eicosanoid PathwayArachidonic Acid CYP450 Pathway
02
Mechanism of action
Inhibition of specific CYP450 enzymes involved in eicosanoid metabolism, such as CYP2C, CYP2J, CYP4A, and CYP4F.
03
Biological functions
Vascular tone regulationInflammation modulationAngiogenesisBlood pressure regulationEndothelial functionOxidative stress responseEicosanoid biosynthesis
04
Disease associations
HypertensionCardiovascular diseaseInflammatory disordersCancerTumorigenesis
05
Safety considerations
Potential for drug-drug interactions due to CYP450 involvement in drug metabolismOff-target effects of CYP450 inhibitorsImbalance in eicosanoid levels leading to unintended physiological consequences
06
Interacting drugs
ω-Hydroxylase inhibitors
2 more in the full profile.
07
Biomarkers
EET levelsHETE levels20-HETE levelsArachidonic acid levelsCYP450 enzyme expression levels
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