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Target intelligence / Profile preview
Cytochrome P450 Enzyme (Ergosterol Biosynthesis)
- Molecular classification
- Enzyme, Cytochrome P450 (CYP superfamily), Monooxygenase
01
Overview
Cytochrome P450 enzymes, particularly CYP51/Erg11, are essential monooxygenases in the ergosterol biosynthesis pathway in fungi. They catalyze key oxidative demethylation reactions, converting lanosterol to ergosterol, a crucial component of fungal cell membranes. These enzymes are major targets for antifungal drugs like azoles, which disrupt membrane formation and lead to fungal cell death.
- Other names
- Erg11CYP51Lanosterol 14α-demethylaseErg5C22 desaturase
02
Mechanism of action
Inhibition of CYP51/Erg11, blocking demethylation of lanosterol
03
Biological functions
Steroid biosynthesisErgosterol biosynthesisOxidationDemethylationDesaturation
04
Disease associations
Infection
05
Interacting drugs
Azole antifungals
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