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Target intelligence / Profile preview
Cytochrome P450 Enzymes Involved in Steroidogenesis (Steroidogenic CYPs)
- Target
- Steroidogenic CYPs
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 enzymes (CYPs) are a superfamily of heme-containing monooxygenases that play essential roles in the biosynthesis of steroid hormones. In human steroidogenesis, key CYP enzymes like CYP11A1, CYP17A1, CYP19A1, CYP21A2, CYP11B1, and CYP11B2 catalyze sequential oxidation reactions converting cholesterol into biologically active steroid hormones. Their activity is essential for sexual differentiation, reproductive function, blood pressure regulation, and stress response. Disorders affecting these enzymes can lead to various diseases, making them important drug targets. Examples include aromatase inhibitors targeting CYP19A1 for estrogen-dependent cancers and abiraterone inhibiting CYP17A1 for prostate cancer.
- Other names
- Steroidogenic cytochrome P450sSteroid hormone biosynthesis enzymesCYP11A1CYP17A1CYP19A1CYP21A2CYP11B1CYP11B2
02
Mechanism of action
Inhibition of steroid hormone synthesis
03
Biological functions
Steroid hormone biosynthesisCholesterol metabolismSexual differentiationReproductive functionRegulation of blood pressureStress response
04
Disease associations
Congenital adrenal hyperplasiaCushing's syndromeHypertensionInfertilityProstate cancerBreast cancerEndocrine disorders
05
Safety considerations
Hormonal imbalancesDrug-drug interactionsAdverse effects on multiple endocrine pathwaysPotential for off-target effects
06
Interacting drugs
Aromatase inhibitors
3 more in the full profile.
07
Biomarkers
Hormone levels (e.g., cortisol, aldosterone, androgens, estrogens)Enzyme activity assaysGenetic mutations in CYP genes
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