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Target intelligence / Profile preview
Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1)
- Target
- CYP1A1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome P450 superfamily of enzymes involved in the metabolism of drugs, xenobiotics, and endogenous compounds. It is primarily found in extrahepatic tissues and is inducible by polycyclic aromatic hydrocarbons (PAHs). CYP1A1 can both activate procarcinogens into carcinogenic metabolites and detoxify certain compounds, playing a complex role in cancer development. Genetic polymorphisms can affect its inducibility and influence cancer susceptibility. It metabolizes endogenous substrates such as fatty acids, steroid hormones, vitamins (notably retinoic acid), and eicosanoids.
- Other names
- Aryl hydrocarbon hydroxylaseAHH
02
Mechanism of action
CYP1A1 is a monooxygenase that catalyzes the oxidation of various substrates, including xenobiotics and endogenous compounds, using molecular oxygen and NADPH. It can activate procarcinogens into carcinogenic metabolites.
03
Biological functions
Xenobiotic metabolismDrug metabolismSteroid synthesisCholesterol synthesisLipid synthesisActivation of procarcinogensDetoxification of xenobiotics
04
Disease associations
CancerAryl Hydrocarbon Hydroxylase Inducibility syndrome
05
Safety considerations
Metabolic activation of procarcinogensGenetic polymorphisms affecting inducibility and cancer susceptibility
06
Interacting drugs
Theophylline
3 more in the full profile.
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