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Cytochrome P450 family 1 subfamily B member 1 (CYP1B1)
- Target
- CYP1B1
- Molecular classification
- Enzyme, Monooxygenase, Oxidoreductase, Cytochrome P450
01
Overview
Cytochrome P450 1B1 (CYP1B1) is a heme-containing monooxygenase involved in the metabolism of endogenous and exogenous compounds. It participates in Phase I reactions of drug and xenobiotic metabolism, cholesterol synthesis, steroid hormone metabolism, and is critical for estrogen metabolism. CYP1B1 is predominantly expressed in extrahepatic tissues and plays a role in eye development and cancer risk. Its expression is regulated by the aryl hydrocarbon receptor and it modulates redox balance within cells.
- Other names
- Cytochrome P450 1B1
02
Mechanism of action
Inhibition of CYP1B1 enzymatic activity (not specified in the document but implied by therapeutic relevance)
03
Biological functions
Drug metabolismXenobiotic metabolismCholesterol synthesisSteroid hormone metabolismEstrogen metabolismRedox homeostasis
04
Disease associations
Primary congenital glaucomaPeters anomalyCancerIschemic retinopathy
05
Safety considerations
Potential for increased susceptibility to various cancers due to altered expression/activity.Dysregulation of estrogen metabolism leading to cancer risk.Increased oxidative stress.
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