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Target intelligence / Profile preview
Cytochrome P450 family 11 subfamily A member 1 (CYP11A1)
- Target
- CYP11A1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 11A1 (CYP11A1), also known as cholesterol side-chain cleavage enzyme or P450scc, is a mitochondrial enzyme that catalyzes the first and rate-limiting step in steroid hormone biosynthesis. It converts cholesterol into pregnenolone, the precursor for all steroid hormones. Mutations in CYP11A1 can lead to congenital adrenal insufficiency.
- Other names
- Cholesterol side-chain cleavage enzymeP450scc
02
Mechanism of action
Inhibition of cholesterol side-chain cleavage
03
Biological functions
Steroid hormone biosynthesisCholesterol metabolismVitamin D metabolism
04
Disease associations
Congenital adrenal hyperplasiaDisorders of sexual developmentSteroidogenic defects
05
Safety considerations
Potential for drug-drug interactions due to CYP450 inhibitionHormonal imbalances
06
Interacting drugs
Ketoconazole
2 more in the full profile.
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