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Cytochrome P450 Family 11 Subfamily B Member 1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 11B1 is a mitochondrial enzyme catalyzing the final step in cortisol and corticosterone biosynthesis. It hydroxylates steroids at the C-11β position. Mutations lead to congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency, causing impaired cortisol synthesis, accumulation of mineralocorticoid precursors, and excess androgen production.
- Other names
- Steroid 11-beta-hydroxylaseCYP11B1
02
Mechanism of action
Inhibition of steroid 11-beta-hydroxylation
03
Biological functions
Glucocorticoid biosynthesisMineralocorticoid biosynthesisSteroid hormone biosynthesisHydroxylation
04
Disease associations
Congenital adrenal hyperplasiaHypertensionSteroid disorders
05
Safety considerations
Corticosteroid replacement therapy side effectsVirilizationHypertension
06
Biomarkers
11-deoxycortisolCortisolAdrenal androgens
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