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Target intelligence / Profile preview
Cytochrome P450 family 17 subfamily A member 1 (CYP17A1)
- Target
- CYP17A1
- Molecular classification
- Enzyme, Cytochrome P450 superfamily
01
Overview
Cytochrome P450 17A1 (CYP17A1) is a crucial enzyme in human steroid hormone biosynthesis, catalyzing two key reactions: 17α-hydroxylation and 17,20-lyase activity. These activities are essential for the production of glucocorticoids, sex steroids, and mineralocorticoids. The enzyme is localized to the endoplasmic reticulum of cells primarily within adrenal glands, gonads, and placenta. Mutations or deficiencies in CYP17A1 can lead to several disorders, including congenital adrenal hyperplasia and pseudohermaphroditism. Altered CYP17A1 function has implications for diseases such as polycystic ovary syndrome, adrenarche abnormalities, prostate cancer, and other endocrine disorders.
- Other names
- Cytochrome P450 17A117alpha-hydroxylase17,20-lyase
02
Mechanism of action
Inhibition of CYP17A1 enzymatic activity
03
Biological functions
Steroid hormone biosynthesisGlucocorticoid productionSex hormone productionMineralocorticoid production17α-hydroxylase activity17,20-lyase activityIron ion bindingOxidoreductase activity
04
Disease associations
Congenital adrenal hyperplasia due to deficiencyPseudohermaphroditismPolycystic ovary syndromeAdrenarche abnormalitiesProstate cancerEndocrine disorders
05
Safety considerations
Impaired synthesis of glucocorticoidsImpaired synthesis of sex steroids
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