Cytochrome P450 family 2 subfamily AB member 1, pseudogene (CYP2AB1P)

CYP2AB1P is designated as a pseudogene within the human genome, meaning it closely resembles functional cytochrome P450 genes but contains multiple genetic defects that prevent it from producing a functional enzyme[1]. Specifically, it has a faulty exon boundary, early stop codons, frameshifts, and missing coding regions that result in a nonfunctional sequence[1]. As a pseudogene, CYP2AB1P does not encode a protein and is not a therapeutic target, receptor, enzyme, or transporter. There is no evidence that CYP2AB1P serves as a biomarker, directly contributes to regulatory RNA pathways, or interacts with any drugs[1]. While pseudogenes can occasionally have regulatory roles at the RNA level, there is no literature supporting any such activity for CYP2AB1P itself, and it is not associated with specific diseases, mechanisms of action, or safety concerns. Its inclusion as a drug target is incorrect. CYP2AB1P does not function as a protein-coding enzyme or therapeutic target; its status as a pseudogene renders it biologically inert with respect to drug targeting or disease intervention[1]. Its mention in target lists is likely due to automated gene annotation, and it should not be considered a true molecular target[1].

Other names

Cytochrome P450, family 2, subfamily AB, polypeptide 1, pseudogeneCYP2AB1P