Cytochrome P450 family 2 subfamily C isozymes (CYP2C isozymes)

CYP2C isozymes are a subfamily of the cytochrome P450 superfamily of membrane-bound enzymes, predominantly expressed in the liver and responsible for the metabolism of approximately 20% of clinically used drugs. Individual isozymes like CYP2C19 and CYP2C9 are highly polymorphic, resulting in significant variability in drug response, efficacy, and risk of adverse effects among patients. Beyond drug metabolism, CYP2C enzymes are involved in the synthesis of cholesterol, steroids, and lipid-derived signaling molecules. Polymorphisms in these genes are major determinants in pharmacogenomics, impacting personalized drug therapy. For structured data, it is advisable to reference specific isozymes (e.g., "Cytochrome P450 2C19") rather than the whole "CYP2C isozymes" cluster, as the individual members have distinct substrate specificities and clinical roles.

Other names

CYP2C enzymesCYP2C familyCytochrome P450 2C subfamily

Drug metabolism by hydroxylation, oxidation, and epoxygenation. Conversion of prodrugs to active forms (e.g., clopidogrel). Inhibition or induction by concomitantly administered drugs, affecting plasma concentrations.