Target intelligence / Profile preview

Cytochrome P450 family 2 subfamily D member 6 (CYP2D6)

Target: CYP2D6
Molecular classification: Enzyme, Cytochrome P450

Overview

Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) is an enzyme primarily expressed in the liver that metabolizes approximately 20-25% of clinically used drugs. Genetic variations in the *CYP2D6* gene can result in significant inter-individual differences in drug metabolism rates, leading to poor, intermediate, extensive, or ultrarapid metabolizer phenotypes. These differences can affect drug efficacy and toxicity.

Other names: P450-DB1P450C2DCYP2DL1CYP2DCPD6

Mechanism of action

Hydroxylation, demethylation, and dealkylation of various drugs and endogenous compounds.

Biological functions

Monooxygenase activityOxidoreductase activityDrug metabolismSteroid synthesisLipid synthesisXenobiotic metabolismHydroxylationDemethylationDealkylation

Disease associations

Drug metabolism disordersNeuroleptic malignant syndromeVariable responses/adverse effects with psychotropic medications

Safety considerations

Adverse drug reactions due to altered metabolismTherapeutic failure due to altered metabolismIncreased risk of side effects/toxicity in poor metabolizersReduced efficacy for some drugs in ultrarapid metabolizers

Interacting drugs

Amitriptyline

16 more in the full profile.

Biomarkers

CYP2D6 genotype/phenotype

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