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Target intelligence / Profile preview
Cytochrome P450 family 26 subfamily B member 1 (CYP26B1)
- Target
- CYP26B1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 26B1 (CYP26B1) is a monooxygenase enzyme that catalyzes the hydroxylation and inactivation of all-trans-retinoic acid, playing a crucial role in retinoid homeostasis. It is essential for proper skeletal, limb, and lymphatic system development. Dysregulation of CYP26B1 is implicated in limb malformations, lymphedema, and certain cancers like colorectal cancer.
- Other names
- P450RAI2
02
Mechanism of action
Inhibitors of CYP26B1 would increase retinoic acid levels; activators would decrease retinoic acid levels.
03
Biological functions
Retinol metabolismRetinoid homeostasisLimb developmentSkeletal developmentLymphatic system developmentInactivation of all-trans-retinoic acid
04
Disease associations
Limb malformationsLymphedemaColorectal cancer
05
Safety considerations
Altered retinoid signalingDevelopmental abnormalities (if targeted during pregnancy)
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