Cytochrome P450 3A (CYP3A)

Cytochrome P450 3A (CYP3A) refers to a subfamily within the cytochrome P450 superfamily of enzymes. These are heme-thiolate monooxygenases that play a central role in the oxidative metabolism of both endogenous and exogenous compounds, including drugs, hormones, toxins, and carcinogens. The CYP3A subfamily is the most abundant group of CYP enzymes in human liver and intestine. CYP3A4 is the most prevalent and clinically significant isoform in adults. They are highly expressed in the liver and small intestine. CYP3A enzymes catalyze monooxygenation reactions using NADPH as an electron donor. Because they metabolize so many pharmaceuticals, drug-drug interactions involving inhibition or induction of CYP3As are common clinical concerns.

Other names

CYP3A subfamilyCytochrome P450 family 3 subfamily A

Oxidative metabolism of drugs and endogenous compounds, leading to their inactivation or activation.