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Target intelligence / Profile preview
Cytochrome P450 family 3 subfamily A member 5 (CYP3A5)
- Target
- CYP3A5
- Molecular classification
- Enzyme, Cytochrome P450 superfamily, Monooxygenase
01
Overview
CYP3A5 is a heme-thiolate monooxygenase enzyme involved in the NADPH-dependent electron transport pathway. It catalyzes the oxidation of a wide range of structurally diverse compounds, including steroids, fatty acids, xenobiotics, and drugs. Genetic polymorphisms significantly affect expression levels among individuals, impacting dosing requirements and drug efficacy/toxicity risk.
- Other names
- CYP3A5
02
Mechanism of action
Oxidative metabolism of various substrates
03
Biological functions
OxidationMetabolism of steroidsMetabolism of fatty acidsMetabolism of xenobioticsDrug metabolism
04
Disease associations
Drug metabolism variabilityPharmacogenomic implications
05
Safety considerations
Drug interactions due to altered metabolismVariable drug efficacy/toxicity based on genotypeRace-based dosing adjustments needed (e.g., tacrolimus)
06
Interacting drugs
Nifedipine
4 more in the full profile.
07
Biomarkers
CYP3A5 genotype
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