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Target intelligence / Profile preview
Cytochrome P450 Family 3 Subfamily A Member 7 (CYP3A7)
- Target
- CYP3A7
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
CYP3A7 is a member of the cytochrome P450 superfamily, primarily expressed in the fetal and neonatal liver. It functions as a monooxygenase, catalyzing the metabolism of steroid hormones like DHEA-S and testosterone, as well as certain drugs and xenobiotics. While expression declines after birth, CYP3A7 plays a crucial role in fetal development and can influence drug metabolism in neonates. Genetic variations may impact chemotherapy response in cancer patients.
02
Mechanism of action
Catalyzes the metabolism of steroid hormones and xenobiotics via monooxygenase activity.
03
Biological functions
Steroid hormone metabolismXenobiotic metabolismEstriol synthesisDrug metabolism
04
Disease associations
Adrenal hyperplasiaCancer
05
Safety considerations
Variations can influence drug metabolism efficiency, particularly in neonates.Certain alleles may be linked with altered responses to chemotherapy drugs.
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