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Cytochrome P450 family 4 subfamily A member 11 (None)
- Target
- None
- Molecular classification
- Enzyme, Monooxygenase, Heme-thiolate protein, Cytochrome P450
01
Overview
Cytochrome P450 4A11 (CYP4A11) is a monooxygenase enzyme involved in the metabolism of fatty acids, particularly the ω-hydroxylation of medium-chain fatty acids and the synthesis of 20-HETE. It plays a role in regulating blood flow, blood pressure, and kidney function. Genetic variants are associated with hypertension and ischemic stroke. Sesamin is known inhibitor.
- Other names
- 20-HETE synthase20-hydroxyeicosatetraenoic acid synthaseCYP4A2CYP4AII
02
Mechanism of action
Inhibition of CYP4A11 activity leading to decreased synthesis of 20-HETE
03
Biological functions
Metabolism of fatty acids and oxylipinsSynthesis of signaling moleculesRegulation of blood flowRegulation of vascularizationRegulation of blood pressureKidney tubule ion absorption
04
Disease associations
HypertensionCerebral infarction (ischemic stroke)
05
Interacting drugs
Sesamin
06
Biomarkers
Plasma/urinary levels of 20-HETE
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