Cytochrome P450 family 4 subfamily F member 3 (CYP4F3)

Cytochrome P450 family 4 subfamily F member 3 (CYP4F3) is a human enzyme of the cytochrome P450 superfamily, primarily involved in the omega-oxidation of various fatty acids and bioactive lipids, including leukotriene B4 and arachidonic acid[1][2][5]. CYP4F3 exists in multiple tissue-specific isoforms (CYP4F3A and CYP4F3B), with distinct substrate preferences: CYP4F3A is mainly in leukocytes and inactivates leukotriene B4, a key inflammatory mediator, whereas CYP4F3B predominates in the liver and converts arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE), a lipid regulator of vascular tone and blood pressure[1][2][5]. Genetic variants in CYP4F3 are linked to susceptibility for inflammatory diseases and possibly modulate host responses to infection[1]. CYP4F3 activity influences inflammation resolution, fatty acid degradation, and vascular physiology and has regulatory roles in several disease states through lipid mediator metabolism[1][2][5].

Other names

Cytochrome P450 4F3CYP4F3LTB4H20-HETE synthaseCYP4F20-hydroxyeicosatetraenoic acid synthaseCYPIVF3Cytochrome P450-LTB-omegaDocosahexaenoic acid omega-hydroxylase CYP4F3Leukotriene-B(4) 20-monooxygenase 2Leukotriene-B(4) omega-hydroxylase 2CPF3Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 Omega Hydroxylase)Leukotriene B4 omega hydroxylaseLeukotriene-B4 20-monooxygenase[2]

Drugs targeting CYP4F3 would act through inhibition or modulation of its omega-oxidation activity, affecting the metabolism of leukotriene B4 and potentially 20-HETE synthesis[1][2][5].