Cytochrome P450 family 4 subfamily F member 8 (CYP4F8)

Cytochrome P450 family 4 subfamily F member 8 (CYP4F8) is a microsomal monooxygenase enzyme belonging to the cytochrome P450 superfamily. CYP4F8 catalyzes omega-1 and omega-2 hydroxylation of prostaglandins (especially PGH1, PGH2, and PGI2) and polyunsaturated fatty acids, and performs epoxidation reactions on long-chain fatty acids. It is most highly expressed in human seminal vesicles and various epithelial tissues, supporting the formation of 19-hydroxy prostaglandins—predominant in seminal fluid—through lipid oxidations. Recombinant studies show CYP4F8 also generates specific eicosanoid metabolites that regulate inflammation and tissue function. Dysregulation of CYP4F8 is implicated in prostate cancer, where elevated activity may support cell growth, and in skin diseases (psoriasis), where altered expression affects keratinocyte proliferation and lipid oxidative balance. CYP4F8 is part of a cluster of cytochrome P450 genes on chromosome 19. No clinical drugs currently target CYP4F8 directly, but its tissue-selective liability and role in disease make it a candidate therapeutic target for future research.

Other names

Cytochrome P450 4F8CYP4F8CYPIVF8CPF8Cytochrome P450, family 4, subfamily F, polypeptide 8Cytochrome P450, subfamily IVF, polypeptide 8Flavoprotein-linked monooxygenaseMicrosomal monooxygenase

Not applicable: No clinical drugs specifically approved to target CYP4F8 thus far. Interaction with endogenous substrates (prostaglandins, fatty acids): primarily hydroxylation and epoxidation as monooxygenase