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Cytochrome P450 Family 4 Subfamily V Member 2 (None)

Target: None
Molecular classification: Enzyme, Cytochrome P450, Monooxygenase

Overview

CYP4V2 is a member of the cytochrome P450 superfamily of monooxygenases. It is involved in the omega-hydroxylation of fatty acids, particularly in ocular tissues, and plays a role in lipid metabolism. Mutations in CYP4V2 cause Bietti crystalline dystrophy, a retinal degenerative disease. It acts as a selective omega-hydroxylase for saturated medium-chain fatty acids with high catalytic efficiency toward myristic acid.

Other names: BCDCP4V2_HUMANCYP4AH1cytochrome P450 4V2

Mechanism of action

HET0016 is a nanomolar inhibitor specific for CYP4V2, inhibiting its omega-hydroxylation activity.

Biological functions

Fatty acid omega-hydroxylationFatty acid oxidationMetal ion bindingIron ion bindingHeme bindingOxidoreductase activity (acting on paired donors)

Disease associations

Bietti Crystalline DystrophyDeep Venous Thrombosis (potential association)

Safety considerations

Inhibition of CYP4V2 may affect lipid metabolism, potentially leading to unintended consequences.The precise physiological role of CYP4V2 is incompletely understood, making it difficult to predict all potential side effects of therapeutic modulation.

Interacting drugs

HET0016

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