Cytochrome P450 family 4 subfamily X member 1 (CYP4X1)

Cytochrome P450 family 4 subfamily X member 1 (CYP4X1) is a member of the cytochrome P450 superfamily of enzymes, functioning as a monooxygenase that catalyzes diverse reactions including the metabolism of arachidonic acid and the endocannabinoid anandamide[1][2][4]. CYP4X1 is highly expressed in the brain, with lower expression in tissues such as prostate, lung, and neurovascular systems[1][4]. It is implicated in the regulation of fatty acid and endocannabinoid metabolism, neurovascular function, and possibly energy homeostasis, as knockout mouse models display increased body weight and adiposity[4]. Its role in human disease is under investigation, with some studies connecting its expression to tumor biology (notably in brain and breast cancers) and to rare neurological disorders[2][4]. Despite these links, CYP4X1 remains an orphan enzyme, with limited knowledge about its physiological substrates, drug interactions, or therapeutic applications[1][4].

Other names

CYP4X1Cytochrome P450 4X1CYPIVX1Cytochrome P450 family 4 subfamily X polypeptide 1UNQ1929/PRO4404MGC40051

Inhibition of monooxygenase activity affecting fatty acid and endocannabinoid metabolism (inferred from the enzyme’s biochemical role) Potential modulation of neurovascular signaling via alteration of arachidonic acid and anandamide metabolism[4]